Key Takeaways:

• Argues, based on animal studies, that calorie restriction with optimal nutrition (CRON) can significantly extend lifespan and delay age-related diseases.
• Provides structured guidelines for sharply reducing calories while maintaining vitamin and mineral adequacy—essentially a blueprint for human CRON experiments.
• Influenced later calorie-restriction communities and anti-aging research, embedding the idea that aging might be modulated by diet, not just genetics.